Convallaria keiskei as a novel therapeutic alternative for salivary gland cancer treatment by targeting myeloid cell leukemia‐1

@article{Lee2016ConvallariaKA,
  title={Convallaria keiskei as a novel therapeutic alternative for salivary gland cancer treatment by targeting myeloid cell leukemia‐1},
  author={Haeng-Eun Lee and Jeong-Seok Nam and Ji-Ae Shin and In-Sun Hong and In-Hyoung Yang and Myung-jo You and Sung-Dae Cho},
  journal={Head \& Neck},
  year={2016},
  volume={38}
}
Various chemotherapeutic agents have been used largely for the treatment of salivary gland cancer. However, results are disappointing, and these agents can cause some serious side effects. Therefore, recent studies have focused on the possible roles of natural products to overcome these limitations. 
A Novel Therapeutic Approach for Colorectal Cancer Stem Cells: Blocking the PI3K/Akt Signaling Axis With Caffeic Acid
TLDR
It is found that caffeic acid effectively suppresses self-renewal capacity, stem-like characteristics, and migratory capacity of CD44+ and CD133+ colorectal CSCs in vitro and in vivo, and it is revealed that PI3K/Akt signaling may be linked to multiple colore ectopic CSC-associated characteristics, such as radio-resistance,stem-like property, and tumorigenic potential.
Molecular mechanism underlying the apoptotic modulation by ethanol extract of Pseudolarix kaempferi in mucoepidermoid carcinoma of the salivary glands
TLDR
It is revealed that EEPK-induced alterations of Mcl-1 inhibition and JNK/Bcl-2 phosphorylation cause apoptosis and provided basic preclinical data for future clinical trials regarding therapy for patients with MEC.
Development of 19 novel microsatellite markers of lily-of-the-valley (Convallaria, Asparagaceae) from transcriptome sequencing
TLDR
To assess the genetic structure, diversity and demographic history of Convallaria species, 19 novel microsatellite markers were developed based on transcriptome data of C. keiskei and seven of the 19 loci showed significant deviation from Hardy–Weinberg equilibrium.

References

SHOWING 1-10 OF 78 REFERENCES
An overview of the rare parotid gland cancer
TLDR
The current development status of novel radiation therapy and targeted therapeutics, focusing on intensity-modulated radiation therapy (IMRT), and epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) blockages, which are showing promise for improving parotid gland cancer management are presented.
Digitoxin is a potential anticancer agent for several types of cancer.
  • J. Haux
  • Biology
    Medical hypotheses
  • 1999
The ability of digitalis to block cell proliferation has been well established for some time. Recently, digitalis in non-toxic concentrations has been showed to induce apoptosis in different
Systemic therapy in the palliative management of advanced salivary gland cancers.
  • S. Laurie, L. Licitra
  • Medicine
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2006
TLDR
There is a need for a determined, coordinated effort to conduct high-quality clinical trials in patients with advanced salivary gland cancer of these histologies, with an emphasis on the potential role of targeted agents.
Peripheral neuropathy induced by paclitaxel: recent insights and future perspectives.
TLDR
This review focuses on recent advances in the etiology of paclitaxel-mediated peripheral neurotoxicity, and discusses current and ongoing strategies for amelioration of this side effect.
Systemic therapies for recurrent and/or metastatic salivary gland cancers
TLDR
Multicentre cooperative group clinical trials are required to assess novel therapies to maximize patient resources in this uncommon tumor.
Anti-myeloma effect of homoharringtonine with concomitant targeting of the myeloma-promoting molecules, Mcl-1, XIAP, and β-catenin
TLDR
HHT-induced apoptosis appears to be mediated via both intrinsic and extrinsic apoptosis pathways, and the resultant imbalance between BH3-only proteins and Mcl-1 may be pivotal for apoptosis by HHT.
Digitoxin as an anticancer agent with selectivity for cancer cells: possible mechanisms involved
TLDR
It is proposed that the inhibition of glycolysis may be a key mechanism by which this natural product selectively targets cancer cells in patients with cancer.
Combinatorial strategies employing nutraceuticals for cancer development
TLDR
The results of those studies that report combinatorial cancer chemopreventive action of various nutraceuticals and their combinations with anticancer drugs are summarized.
Management and Outcome of Patients With Mucoepidermoid Carcinoma of Major Salivary Gland Origin: A Single Institution's 30‐Year Experience
TLDR
Predicting clinical outcome of Mucoepidermoid carcinoma, one of the most frequent epithelial malignancies of the salivary glands, is challenging.
Mcl-1 is a potential therapeutic target in multiple types of cancer
  • C. Akgul
  • Biology, Chemistry
    Cellular and Molecular Life Sciences
  • 2008
TLDR
Inhibition of its expression and/or neutralization of its anti-apoptotic function will rapidly make Mcl-1-dependent cells more susceptible to apoptosis and provide an opportunity to combat several types of cancers.
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