Conus Venom Peptide Pharmacology

@article{Lewis2012ConusVP,
  title={Conus Venom Peptide Pharmacology},
  author={R. Lewis and S. Dutertre and I. Vetter and M. Christie},
  journal={Pharmacological Reviews},
  year={2012},
  volume={64},
  pages={259 - 298}
}
Conopeptides are a diverse group of recently evolved venom peptides used for prey capture and/or defense. Each species of cone snails produces in excess of 1000 conopeptides, with those pharmacologically characterized (∼0.1%) targeting a diverse range of membrane proteins typically with high potency and specificity. The majority of conopeptides inhibit voltage- or ligand-gated ion channels, providing valuable research tools for the dissection of the role played by specific ion channels in… Expand
Conotoxins and Other Conopeptides
Conotoxins: Structure, Therapeutic Potential and Pharmacological Applications.
Therapeutic potential of cone snail venom peptides (conopeptides).
Discovery of a new subclass of α-conotoxins in the venom of Conus australis.
Molecular Engineering of Conus Peptides as Therapeutic Leads.
Glycosylation of Conotoxins
Cone Snails: A Big Store of Conotoxins for Novel Drug Discovery
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References

SHOWING 1-10 OF 470 REFERENCES
Identification of a Novel Class of Nicotinic Receptor Antagonists
Development of small molecules that mimic the binding of ω-conotoxins at the N-type voltage-gated calcium channel
Conus venoms: a rich source of novel ion channel-targeted peptides.
Discovery and development of the χ-conopeptide class of analgesic peptides.
  • R. Lewis
  • Chemistry, Medicine
  • Toxicon : official journal of the International Society on Toxinology
  • 2012
δ-Conotoxin Structure/Function through a Cladistic Analysis†
New conopeptides of the D-superfamily selectively inhibiting neuronal nicotinic acetylcholine receptors.
Conantokins: peptide antagonists of NMDA receptors.
Conotoxins and their potential pharmaceutical applications
Pruning nature: Biodiversity-derived discovery of novel sodium channel blocking conotoxins from Conus bullatus.
...
1
2
3
4
5
...