Contryphans from Conus textile venom ducts.

  title={Contryphans from Conus textile venom ducts.},
  author={Elsie C. Jimenez and Maren Watkins and Laura J. Juszczak and Lourdes J. Cruz and Baldomero M Olivera},
  journal={Toxicon : official journal of the International Society on Toxinology},
  volume={39 6},
Contryphans are unusual Conus peptides which contain a distinctive post-translational modification, D-tryptophan or D-leucine. cDNA clones encoding new contryphans from the mollusc-hunting cone snail Conus textile were identified and the inferred mature peptides were synthesized: contryphan-Tx (Gly-Cys-Hyp-D-Trp-Gln-Pro-Tyr-Cys-NH(2)), Leu-contryphan-Tx (Cys-Val-D-Leu-Tyr-Pro-Trp-Cys-NH(2)) and contryphan R/Tx which is identical to contryphan-R [Jimenez et al., 1996. Contryphan is a D… CONTINUE READING
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