• Medicine
  • Published in
    American journal of…
    2002

Controversy: PPARgamma as a target for treatment of colorectal cancer.

@article{Gupta2002ControversyPA,
  title={Controversy: PPARgamma as a target for treatment of colorectal cancer.},
  author={Rajnish A. Gupta and Raymond N. Dubois},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2002},
  volume={283 2},
  pages={
          G266-9
        }
}
Colorectal cancer (CRC) represents a significant cause of morbidity and mortality worldwide. Recently, ligands for the nuclear hormone receptor peroxisome proliferator-activated receptor gamma (PPARgamma) have exhibited promise in the treatment of CRC. For example, activation of PPARgamma reduces the proliferation of cultured CRC cells grown in vitro or in vivo using the nude mouse xenograft model of tumor growth. Furthermore, agonists of the receptor also reduce the development of… CONTINUE READING

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