Controversies of Pioglitazone in the Management of Diabetes Mellitus


Type II-diabetes mellitus (T2DM) is a chronic metabolic disorder which is treated with oral hypoglycaemic agents including pioglitazone. The present work is aimed to collect a brief profile of pioglitazone, belonging to the thiazolidinedione class and controversies surrounding its use. Pioglitazone which was marketed in 1999 acts on the nuclear peroxisome… (More)