Controversies in pharmacotherapy of pain management.

  title={Controversies in pharmacotherapy of pain management.},
  author={Mellar P Davis and Declan Walsh and Ruth L Lagman and Susan B Legrand},
  journal={The Lancet. Oncology},
  volume={6 9},
Since the establishment of the WHO three-step ladder for management of cancer pain, several controversies have arisen, which are partly due to new drug development, reformulations of older analgesics, and technological advancements. As a result, clinicians need clarification of several questions. Is morphine the opioid of choice for moderate to severe pain in cancer? Should combinations of opioids be used? When should spinal opioids be used to treat pain in cancer? What are the appropriate… CONTINUE READING