Controversial Therapeutics: The β‐Adrenergic Antagonist and Cocaine‐Associated Cardiovascular Complications Dilemma

@article{Schurr2014ControversialTT,
  title={Controversial Therapeutics: The β‐Adrenergic Antagonist and Cocaine‐Associated Cardiovascular Complications Dilemma},
  author={James W Schurr and Brenda Gitman and Yuly G Belchikov},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
  year={2014},
  volume={34}
}
  • James W Schurr, Brenda Gitman, Yuly G Belchikov
  • Published 2014
  • Medicine
  • Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
  • Cocaine abuse is associated with cardiovascular complications that include chest pain and myocardial infarction. Traditional therapy for these conditions includes a β‐adrenergic antagonist. However, guidelines released in 2008 recommended against this treatment option because of the prevailing theory that cocaine will potentiate vasospasm secondary to unopposed α‐adrenergic effects. Subsequently, further evidence and updated guidelines have become available, debunking this claim. Current… CONTINUE READING
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