Controlling transferrin receptor trafficking with GPI-valence in bloodstream stage African trypanosomes

@inproceedings{Tiengwe2017ControllingTR,
  title={Controlling transferrin receptor trafficking with GPI-valence in bloodstream stage African trypanosomes},
  author={Calvin Tiengwe and Peter J Bush and James D Bangs},
  booktitle={PLoS pathogens},
  year={2017}
}
Bloodstream-form African trypanosomes encode two structurally related glycosylphosphatidylinositol (GPI)-anchored proteins that are critical virulence factors, variant surface glycoprotein (VSG) for antigenic variation and transferrin receptor (TfR) for iron acquisition. Both are transcribed from the active telomeric expression site. VSG is a GPI2 homodimer; TfR is a GPI1 heterodimer of GPI-anchored ESAG6 and ESAG7. GPI-valence correlates with secretory progression and fate in bloodstream… CONTINUE READING
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