Controlling transcriptional programs for cellular adaptation by chromatin regulation.

@article{Kim2011ControllingTP,
  title={Controlling transcriptional programs for cellular adaptation by chromatin regulation.},
  author={Sang Cheol Kim and Jung Kyoon Choi},
  journal={Molecular bioSystems},
  year={2011},
  volume={7 5},
  pages={1713-9}
}
Gene expression is dynamically reprogrammed during growth control and stress responses, which are two key processes of cellular adaptation. Single-gene studies suggest that gene regulatory patterns of the two processes commonly show high environmental responsiveness, but contrast in terms of regulatory flexibility. Our whole-genome analysis shows that the growth and stress genes are associated with activated and repressed chromatin, respectively, which can modulate the responsiveness of… CONTINUE READING