Controlling the urge for a Ca(2+) surge: all-or-none Ca(2+) release in neurons.

@article{Usachev1999ControllingTU,
  title={Controlling the urge for a Ca(2+) surge: all-or-none Ca(2+) release in neurons.},
  author={Yuriy M Usachev and Stanley A Thayer},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  year={1999},
  volume={21 9},
  pages={743-50}
}
Changes in the intracellular calcium concentration ([Ca2+]i) convey signals that are essential to the life and death of neurons. Ca(2+)-induced Ca(2+)-release (CICR), a process in which a modest elevation in [Ca2+]i is amplified by a secondary release of Ca2+ from stores within the cell, plays a prominent role in shaping neuronal [Ca2+]i signals. When CICR becomes regenerative, an explosive increase in [Ca2+]i generates a Ca2+ wave that spreads throughout the cell. A discrete threshold controls… CONTINUE READING