Controlling the spatial distribution of ECM components in degradable PEG hydrogels for tissue engineering cartilage.

@article{Bryant2003ControllingTS,
  title={Controlling the spatial distribution of ECM components in degradable PEG hydrogels for tissue engineering cartilage.},
  author={Stephanie J Bryant and Kristi S Anseth},
  journal={Journal of biomedical materials research. Part A},
  year={2003},
  volume={64 1},
  pages={70-9}
}
In developing a scaffold to support new tissue growth, the degradation rate and mass loss profiles of the scaffold are important design parameters. In this study, hydrogels were prepared by copolymerizing a degradable macromer, poly(lactic acid)-b-poly(ethylene glycol)-b-poly(lactic acid) endcapped with acrylate groups (PEG-LA-DA) with a nondegradable macromer, poly(ethylene glycol) dimethacrylate (PEGDM). The resulting hydrogels exhibited a range of degradation behavior and mass loss profiles… CONTINUE READING

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