Controlling the motor activity of a transcription-repair coupling factor: autoinhibition and the role of RNA polymerase

@inproceedings{Smith2007ControllingTM,
  title={Controlling the motor activity of a transcription-repair coupling factor: autoinhibition and the role of RNA polymerase},
  author={Abigail J. R. Smith and Mark D. Szczelkun and Nigel J. Savery},
  booktitle={Nucleic acids research},
  year={2007}
}
Motor proteins that couple ATP hydrolysis to movement along nucleic acids play a variety of essential roles in DNA metabolism. Often these enzymes function as components of macromolecular complexes, and DNA translocation by the motor protein drives movement of other components of the complex. In order to understand how the activity of motor proteins is regulated within multi-protein complexes we have studied the bacterial transcription-repair coupling factor, Mfd, which is a helicase… CONTINUE READING

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