Controlling specific locomotor behaviors through multidimensional monoaminergic modulation of spinal circuitries.

@article{Musienko2011ControllingSL,
  title={Controlling specific locomotor behaviors through multidimensional monoaminergic modulation of spinal circuitries.},
  author={Pavel Musienko and Rubia van den Brand and Olivia M{\"a}rzendorfer and Roland R. Roy and Yury P. Gerasimenko and V. Reggie Edgerton and Gr{\'e}goire Courtine},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2011},
  volume={31 25},
  pages={9264-78}
}
Descending monoaminergic inputs markedly influence spinal locomotor circuits, but the functional relationships between specific receptors and the control of walking behavior remain poorly understood. To identify these interactions, we manipulated serotonergic, dopaminergic, and noradrenergic neural pathways pharmacologically during locomotion enabled by electrical spinal cord stimulation in adult spinal rats in vivo. Using advanced neurobiomechanical recordings and multidimensional statistical… CONTINUE READING