Controlling sleeping sickness – a review

  title={Controlling sleeping sickness – a review},
  author={Susan Christina Welburn and Ian Maudlin and Pere P. Simarro},
  pages={1943 - 1949}
SUMMARY Following a period characterized by severe epidemics of sleeping sickness, restoration of effective control and surveillance systems has raised the question of eliminating the disease from sub-Saharan Africa. Given sufficient political and financial support, elimination is now considered a reasonable aim in countries reporting zero or less than 100 cases per year. This success may lead health authorities across the affected region to downgrade the disease from ‘neglected’ to simply… 
Challenges of controlling sleeping sickness in areas of violent conflict: experience in the Democratic Republic of Congo
The challenges of carrying out HAT control programmes in general and in a conflict-affected region of DRC are presented and the need for research and development for less complicated, field-adapted tools for diagnosis and treatment is urgently needed.
Tsetse Control and Gambian Sleeping Sickness; Implications for Control Strategy
The case for adding this method of vector control to case detection and treatment of Gambian sleeping sickness is strong and how such a component could be organised is outlined.
The Contribution of Tanzanian National Parks in Controlling the Vectors of Sleeping Sickness
The results show that much control efforts have so far concentrated in Serengeti, Ruaha, Tarangire and Katavi National Parks where tsetse fly challenges are high and the major challenges faced include tsete re-invasion in controlled areas.
Neglected Tropical Diseases and the Millennium Development Goals-why the "other diseases" matter: reality versus rhetoric
This paper responds to what the authors believe are inappropriate criticisms of these programmes and counters accusations of the motives of partners made in recently published papers, and provides a detailed response and update the information on the numbers of global treatments undertaken for NTDs.
The journey towards elimination of gambiense human African trypanosomiasis: not far, nor easy
The elimination of gambiense human African trypanosomiasis is considered feasible, because of the epidemiological vulnerability of the disease, the current state of control, the availability of strategies and tools and international commitment and political will.
Developing Eradication Investment Cases for Onchocerciasis, Lymphatic Filariasis, and Human African Trypanosomiasis: Rationale and Main Challenges
The global health community pays renewed attention to evaluating the feasibility of elimination and eradication of certain communicable diseases, and several neglected tropical diseases (NTDs) are tentatively identified as amenable to eradication.
Evaluating the impact of targeting livestock for the prevention of human and animal trypanosomiasis, at village level, in districts newly affected with T. b. rhodesiense in Uganda
The intervention resulted in a significant decrease in the prevalence of T. b.
Is vector control needed to eliminate gambiense human African trypanosomiasis?
Human African Trypanosomiasis, or sleeping sickness, is a neglected tropical parasitic disease of humans due to trypanosomes transmitted by tsetse flies in sub-Saharan Africa and treatment is still long and difficult to administer despite recent improvements.


Civil conflict and sleeping sickness in Africa in general and Uganda in particular
A review and characterization of the processes by which conflict has contributed to the occurrence of sleeping sickness in Africa is presented, with particular focus on the case of slept sickness in south-eastern Uganda, where incidence increase is expected to continue.
Control and surveillance of African trypanosomiasis. Report of a WHO Expert Committee.
  • J. Baker
  • Medicine
    World Health Organization technical report series
  • 1998
The Natural Progression of Gambiense Sleeping Sickness: What Is the Evidence?
The potential existence and relevance of human trypano-tolerance is considered, and the duration of infectiousness is explored, through a review of published evidence on the natural progression of gambiense HAT in the absence of treatment, and biological considerations.
Public-private partnership works to stamp out sleeping sickness in Uganda.
Reanalyzing the 1900-1920 sleeping sickness epidemic in Uganda.
Analysis of clinical data recorded in the early 1900s shows that the clinical course of sleeping sickness cases during the 1900-1920 epidemic in Uganda was markedly different from T.b. gambiense cases, but similar to T. b.
[The impact of war on the evolution of sleeping sickness in west-central Côte d'Ivoire].
  • D. Kaba, N. Djè, P. Solano
  • Medicine, Political Science
    Tropical medicine & international health : TM & IH
  • 2006
In war, assessing the importance of slept sickness by medical surveys only is very difficult, but detection of sleeping sickness cases by passive surveillance increased.
[Campaign against sleeping sickness in South-West Uganda by trapping tsetse flies].
  • J. Lancien
  • Biology, Medicine
    Annales de la Societe belge de medecine tropicale
  • 1991
An outbreak of human trypanosomiasis due to Trypanosoma brucei rhodesiense has been affecting the Busoga district of Uganda since 1976 and since two years the epidemic area has been extending to the Tororo district.
Duration of symptoms and case fatality of sleeping sickness caused by Trypanosoma brucei rhodesiense in Tororo, Uganda.
The study of the duration of symptoms and the case fatality of T. b.
African trypanosomiasis
This volume will attempt to summarise recent significant findings, outlining the holistic way in which understanding is progressing, encompassing human and livestock disease, disease determinants in both the host and the parasite, and the potential that is arising for novel therapeutics from the often neglected member of the lifecycle, the tsetse fly.