Controlling osteopontin orientation on surfaces to modulate endothelial cell adhesion.

@article{Liu2005ControllingOO,
  title={Controlling osteopontin orientation on surfaces to modulate endothelial cell adhesion.},
  author={Lingyun Liu and Shengfu Chen and Cecilia M. Giachelli and Buddy D. Ratner and Shaoyi Jiang},
  journal={Journal of biomedical materials research. Part A},
  year={2005},
  volume={74 1},
  pages={
          23-31
        }
}
Osteopontin (OPN) is an important extracellular matrix protein that has been shown to impact wound healing, inflammation, and the foreign body reaction, and has been identified as a potential surface component for engineered biomaterials. OPN contains the arginine-glycine-aspartic acid (RGD) moiety that has been shown to mediate cell adhesion through interactions with integrins. In its preferred orientation and conformation on a surface, the functional domains of OPN will be presented to cells… CONTINUE READING
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