Controlling nuclear receptors: the circular logic of cofactor cycles

  title={Controlling nuclear receptors: the circular logic of cofactor cycles},
  author={Valentina Perissi and Michael G. Rosenfeld},
  journal={Nature Reviews Molecular Cell Biology},
Nuclear receptors regulate many biologically important processes in development and homeostasis by their bimodal function as repressors and activators of gene transcription. A finely tuned modulation of the transcriptional activities of nuclear receptors is crucial for determining highly specific and diversified programmes of gene expression. Recent studies have provided insights into the molecular mechanisms that are required to switch between repression and activation functions, the… CONTINUE READING