Controlling myocyte cGMP: phosphodiesterase 1 joins the fray.

CGMP is a central intracellular second-messenger regulating numerous cellular functions. In the cardiac myocyte, cGMP mediates effects of nitric oxide and atrial natriuretic peptide, whereas its counterpart, cAMP, mediates catecholamine signaling. Each cyclic nucleotide has a corresponding primary targeted protein kinase, protein kinase (PK)A for cAMP, and… CONTINUE READING