Controlling murine and rat chronic pain through A3 adenosine receptor activation.


Clinical management of chronic neuropathic pain is limited by marginal effectiveness and unacceptable side effects of current drugs. We demonstrate A(3) adenosine receptor (A(3)AR) agonism as a new target-based therapeutic strategy. The development of mechanoallodynia in a well-characterized mouse model of neuropathic pain following chronic constriction… (More)
DOI: 10.1096/fj.11-201541


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