Controlling multipotent stromal cell migration by integrating "course-graining" materials and "fine-tuning" small molecules via decision tree signal-response modeling.

@article{Wu2011ControllingMS,
  title={Controlling multipotent stromal cell migration by integrating "course-graining" materials and "fine-tuning" small molecules via decision tree signal-response modeling.},
  author={Shan Wu and Alan Wells and Linda G Griffith and Douglas A. Lauffenburger},
  journal={Biomaterials},
  year={2011},
  volume={32 30},
  pages={
          7524-31
        }
}
Biomimetic scaffolds have been proposed as a means to facilitate tissue regeneration by multi-potent stromal cells (MSCs). Effective scaffold colonization requires a control of multiple MSC responses including survival, proliferation, differentiation, and migration. As MSC migration is relatively unstudied in this context, we present here a multi-level approach to its understanding and control, integratively tuning cell speed and directional persistence to achieve maximal mean free path (MFP… CONTINUE READING

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