Controlling misdiagnosis errors in preimplantation genetic diagnosis: a comprehensive model encompassing extrinsic and intrinsic sources of error.

@article{Lewis2001ControllingME,
  title={Controlling misdiagnosis errors in preimplantation genetic diagnosis: a comprehensive model encompassing extrinsic and intrinsic sources of error.},
  author={Cathryn M. Lewis and Tracy Pinel and John C. Whittaker and Alan H. Handyside},
  journal={Human reproduction},
  year={2001},
  volume={16 1},
  pages={43-50}
}
We have developed a mathematical model to explore accuracy of preimplantation genetic diagnosis (PGD) using single cell polymerase chain reaction (PCR). The model encompasses both extrinsic technical errors and intrinsic errors related to nuclear and chromosomal abnormalities. Using estimates for these errors, we have calculated the probability of a serious error (affected embryo diagnosed as unaffected) using a variety of strategies designed to increase the accuracy of PGD. Additional… CONTINUE READING

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