Controlling liposomal drug release with low frequency ultrasound: mechanism and feasibility.

  title={Controlling liposomal drug release with low frequency ultrasound: mechanism and feasibility.},
  author={Avi Schroeder and Yuval Avnir and Sarah Weisman and Yousef Najajreh and Alberto Gabizon and Yeshayahu Talmon and Joseph Kost and Yechezkel Chezy Barenholz},
  journal={Langmuir : the ACS journal of surfaces and colloids},
  volume={23 7},
The ability of low-frequency ultrasound (LFUS) to release encapsulated drugs from sterically stabilized liposomes in a controlled manner was demonstrated. Three liposomal formulations having identical lipid bilayer compositions and a similar size ( approximately 100 nm) but differing in their encapsulated drugs and methods of drug loading have been tested. Two of the drugs, doxorubicin and methylpredinisolone hemisuccinate, were remote loaded by transmembrane gradients (ammonium sulfate and… CONTINUE READING


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