Controlling influenza virus replication by inhibiting its proton channel.

  title={Controlling influenza virus replication by inhibiting its proton channel.},
  author={Lawrence H. Pinto and Robert A. Lamb},
  journal={Molecular bioSystems},
  volume={3 1},
Influenza A and viruses encode minimalistic proton-selective ion channels known as A/M2 and BM2, respectively. The A/M2 channel is the target of the antiviral drug, amantadine. The structural and mechanistic aspects of proton conductance of the viral ion channels are described and the review makes a case for the development of more effective antivirals. 

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