Controlling hydrogelation kinetics by peptide design for three-dimensional encapsulation and injectable delivery of cells.

@article{HainesButterick2007ControllingHK,
  title={Controlling hydrogelation kinetics by peptide design for three-dimensional encapsulation and injectable delivery of cells.},
  author={Lisa A Haines-Butterick and Karthikan Rajagopal and Monica Branco and Daphne A Salick and Ronak V Rughani and Matthew Pilarz and Matthew S Lamm and Darrin J. Pochan and Joel P Schneider},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 19},
  pages={7791-6}
}
A peptide-based hydrogelation strategy has been developed that allows homogenous encapsulation and subsequent delivery of C3H10t1/2 mesenchymal stem cells. Structure-based peptide design afforded MAX8, a 20-residue peptide that folds and self-assembles in response to DMEM resulting in mechanically rigid hydrogels. The folding and self-assembly kinetics of MAX8 have been tuned so that when hydrogelation is triggered in the presence of cells, the cells become homogeneously impregnated within the… CONTINUE READING