Controlling false discoveries in multidimensional directional decisions, with applications to gene expression data on ordered categories.

@article{Guo2010ControllingFD,
  title={Controlling false discoveries in multidimensional directional decisions, with applications to gene expression data on ordered categories.},
  author={Wenge Guo and Sanat K. Sarkar and Shyamal D. Peddada},
  journal={Biometrics},
  year={2010},
  volume={66 2},
  pages={485-92}
}
Microarray gene expression studies over ordered categories are routinely conducted to gain insights into biological functions of genes and the underlying biological processes. Some common experiments are time-course/dose-response experiments where a tissue or cell line is exposed to different doses and/or durations of time to a chemical. A goal of such studies is to identify gene expression patterns/profiles over the ordered categories. This problem can be formulated as a multiple testing… CONTINUE READING