Controlling cell behavior electrically: current views and future potential.
@article{McCaig2005ControllingCB,
title={Controlling cell behavior electrically: current views and future potential.},
author={Colin D. McCaig and Ann M. Rajnicek and Bing Song and Min Zhao},
journal={Physiological reviews},
year={2005},
volume={85 3},
pages={
943-78
}
}Direct-current (DC) electric fields are present in all developing and regenerating animal tissues, yet their existence and potential impact on tissue repair and development are largely ignored. This is primarily due to ignorance of the phenomenon by most researchers, some technically poor early studies of the effects of applied fields on cells, and widespread misunderstanding of the fundamental concepts that underlie bioelectricity. This review aims to resolve these issues by describing: 1) the…
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References
SHOWING 1-10 OF 265 REFERENCES
The responses of cells to electrical fields: a review
- BiologyThe Journal of cell biology
- 1985
The significance of these recent results is increased by the finding that several cell types that normally migrate or grow long distances in embryos respond directionally to surprisingly small fields, and by the concurrent finding that developing embryos produce substantial endogenous currents.
Cellular mechanisms of direct-current electric field effects: galvanotaxis and metastatic disease
- BiologyJournal of Cell Science
- 2004
The galvanotactic responses of strongly metastatic prostate and breast cancer cells are much more prominent, and the cells move in the opposite direction compared with corresponding weakly metastatic cells, which could have important implications for the metastatic process and has clinical implications.
A small, physiological electric field orients cell division.
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 1999
We report on an observation that the orientation of cell division is directed by small, applied electric fields (EFs). Cultured human corneal epithelial cells were exposed to a direct-current EF of…
Electrical fields, nerve growth and nerve regeneration
- BiologyExperimental physiology
- 1991
Electric fields enhance regeneration of damaged PNS and CNS neurones in animals as diverse as lampreys, frogs, rats and guinea‐pigs, but the mechanisms by which fields produce their effects are not understood.
Reaction of cells to the galvanic current in tissue cultures
- Biology
- 1920
The hypothesis of Kappers, that electrical forces are determining factors in the outgrowth and distribution of the different constituents of the nervous system, has been proved to be a fact in pieces of the central nervous system of the chick cultured in vitro.
A role for endogenous electric fields in wound healing.
- BiologyCurrent topics in developmental biology
- 2003
Nerve regeneration and wound healing are stimulated and directed by an endogenous electrical field in vivo
- BiologyJournal of Cell Science
- 2004
An in vivo rat corneal model is used and it is shown that nerve sprouting, the direction of nerve growth and the rate of epithelial wound healing are controlled coordinately by the wound-induced electric field.
Enhanced spinal cord regeneration in lamprey by applied electric fields.
- BiologyScience
- 1981
Enhanced regeneration was observed in the severed giant reticulospinal neurons and processes from giant axons with swollen irregular tips, indicating active growth, were seen in or across the spinal lesion in most of the electrically treated animals.
Hippocampal growth cone responses to focally applied electric fields.
- BiologyJournal of neurobiology
- 1993
It is shown that different growth cones of the same neuron can show differential responsiveness to focally applied electric fields: growth cones on the short, straight processes that are destined to become dendrites, oriented toward the cathode, whereas growth cone on the longest process, the presumptive axon, did not orient.























