Controlling cancer by restricting arginine availability--arginine-catabolizing enzymes as anticancer agents.

Abstract

Interest has recently been revived in enzymes that degrade essential amino acids. Arginine-catabolizing enzymes now predominate and are discussed in this review. Apart from reducing tumor load through cell death occurring as a result of deprivation alone, these catabolic enzymes conveniently leave the remaining malignant cells vulnerable to other… (More)

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@article{Wheatley2004ControllingCB, title={Controlling cancer by restricting arginine availability--arginine-catabolizing enzymes as anticancer agents.}, author={Denys N. Wheatley}, journal={Anti-cancer drugs}, year={2004}, volume={15 9}, pages={825-33} }