Controlling caloric consumption: protocols for rodents and rhesus monkeys.

  title={Controlling caloric consumption: protocols for rodents and rhesus monkeys.},
  author={Thomas D. Pugh and Roger G. Klopp and Richard Weindruch},
  journal={Neurobiology of aging},
  volume={20 2},
One approach for investigating biological aging is to compare control-fed animals with others restricted in calorie intake by 20% or more. Caloric restriction (CR) is the only intervention shown to extend the maximum lifespan of several invertebrates and vertebrates including spiders, fish, rats and mice. The capacity of CR to retard aging in nonhuman primates is now being explored. The rodent studies show that CR opposes the development of many age-associated pathophysiological changes… CONTINUE READING

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