Controlling bursting in cortical cultures with closed-loop multi-electrode stimulation.

@article{Wagenaar2005ControllingBI,
  title={Controlling bursting in cortical cultures with closed-loop multi-electrode stimulation.},
  author={Daniel A. Wagenaar and Radhika Madhavan and Jerome Pine and Steve M. Potter},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2005},
  volume={25 3},
  pages={
          680-8
        }
}
One of the major modes of activity of high-density cultures of dissociated neurons is globally synchronized bursting. Unlike in vivo, neuronal ensembles in culture maintain activity patterns dominated by global bursts for the lifetime of the culture (up to 2 years). We hypothesize that persistence of bursting is caused by a lack of input from other brain areas. To study this hypothesis, we grew small but dense monolayer cultures of cortical neurons and glia from rat embryos on multi-electrode… CONTINUE READING

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