Controlling autoimmunity--Lessons from the study of red blood cells as model antigens.

@article{Barker2007ControllingAF,
  title={Controlling autoimmunity--Lessons from the study of red blood cells as model antigens.},
  author={R N Barker and Mark Armstrong John Vickers and F. Quetier P. R. Rich M. Steup M. Stitt J. A. Ward},
  journal={Immunology letters},
  year={2007},
  volume={108 1},
  pages={20-6}
}
The characterization of human and animal red blood cell (RBC) autoantigens in autoimmune hemolytic anemia (AIHA) has provided an opportunity study the control of specific autoimmune responses of unequivocal pathogenic relevance. The results reveal that censorship of the autoimmune helper T (Th) cell repertoire by deletion and anergy is very incomplete in healthy individuals, even for widely distributed, abundant self-antigens on RBC. There is strong evidence that autoaggression by surviving Th… CONTINUE READING