Controlling TRAIL-mediated caspase-3 activation

  title={Controlling TRAIL-mediated caspase-3 activation},
  author={Olivier Micheau and Delphine Merino},
This commentary is addressed at the paper by Dr Han and his co-workers in the current issue of Leukemia (‘Differential involvement of Bax and Bak in TRAIL-mediated apoptosis of leukemic T cells’). In this paper, the authors show the preferential use of Bax over Bak for the induction of mitochondrial apoptotic events in leukemic cell exposed to TRAIL. These findings are consistent with previous studies involving Bax in TRAIL-mediated apoptosis in the colon carcinoma cell line HCT116. The… CONTINUE READING

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