Controlled trials of inositol in psychiatry

  title={Controlled trials of inositol in psychiatry},
  author={J. Levine},
  journal={European Neuropsychopharmacology},
  • J. Levine
  • Published 1997
  • Psychology, Medicine
  • European Neuropsychopharmacology
  • Inositol is a simple polyol precursor in a second messenger system important in the brain. Cerebrospinal fluid inositol has been reported as decreased in depression. A double-blind controlled trial of 12 g daily of inositol in 28 depressed patients for four weeks was performed. Significant overall benefit for inositol compared to placebo was found at week 4 on the Hamilton Depression Scale. No changes were noted in hematology, kidney or liver function. Since many antidepressants are effective… CONTINUE READING
    118 Citations

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