Controlled trials of inositol in psychiatry

  title={Controlled trials of inositol in psychiatry},
  author={Joseph Levine},
  journal={European Neuropsychopharmacology},
  • J. Levine
  • Published 1 May 1997
  • Psychology, Medicine
  • European Neuropsychopharmacology
Epi‐inositol: A potential antidepressant
Epi‐inositol could be a more effective psychoactive drug than its natural analog and have effects similar to those of myoinositol in reversing lithium–pilocarpine seizures and in reverse lithium‐induced rises in cytidine monophosphorylphosphatidate in cultured cells as does inositol.
Inositol as an add-on treatment for bipolar depression.
These pilot data suggest a controlled study with an adequate sample size, and the appropriate rating scale may demonstrate efficacy for inositol in bipolar depression, and well tolerated with minimal side effects.
Epi-Inositol and inositol depletion: Two new treatment approaches in affective disorder
It is proposed that an inositol-free diet will augment lithium action in mania by enhancing restriction of inositole, and its effect was stronger than that of myoinositol.
Double-Blind, Controlled, Crossover Trial of Inositol Versus Fluvoxamine for the Treatment of Panic Disorder
A double-blind, controlled, random-order crossover study was undertaken to compare the effect of inositol with that of fluvoxamine in panic disorder and found it attractive to patients who are ambivalent about taking psychiatric medication.
Inositol versus placebo augmentation of serotonin reuptake inhibitors in the treatment of obsessive-compulsive disorder: a double-blind cross-over study.
No significant difference was found between the two treatment phases and a previous study suggested that inositol alone is efficacious in OCD.
Inositol reduces depressive-like behaviors in two different animal models of depression
The effect of inositol in animal models of depression supports its possible importance as a new treatment for the disorder, and permits research on its mechanisms of action.
The anxiolytic effect of chronic inositol depends on the baseline level of anxiety
The effect of chronic intraperitoneal and chronic dietary inositol administration in rats was tested in rats that were exposed to a mild and a more severe form of stress, and there was a clear in-crease in number of entries into open arms, suggesting an anxiolytic effect of inposol.
Choline, myo-inositol and mood in bipolar disorder: a proton magnetic resonance spectroscopic imaging study of the anterior cingulate cortex.
The results of this study suggest that bipolar disorder is associated with alterations in the metabolism of cytosolic, choline-containing compounds in the anterior cingulate cortex, consistent with impaired intraneuronal signaling mechanisms.
Inositol for depressive disorders.
It is currently unclear whether or not inositol is of benefit in the treatment of depression, and ongoing studies should reduce this uncertainty.
The antidepressant activity of inositol in the forced swim test involves 5-HT2 receptors


Double-blind, controlled trial of inositol treatment of depression.
This may be the first use of the precursor strategy for a second messenger rather than a neurotransmitter in treating depression, and inositol had a significant antidepressant effect in this study.
Inositol 6 g daily may be effective in depression but not in schizophrenia
Inositol is an important precursor for second messenger synthesis and has been reported to be reduced by lithium treatment in rat brain and in human CSF in depression. An open trial of 6 g/day in 11
Inositol may worsin attention deficit disorder with hyperactivity
Evaluating the effects of oral inositol in children with ADDH in a double‐blind, cross‐over, placebo‐controlled manner found inositols to be effective in depression.
Efficacy and tolerability of serotonin transport inhibitors in obsessive-compulsive disorder. A meta-analysis.
While the results of this meta-analysis support the superiority of clomipramine, head-to-head, double-blind comparisons of these compounds would be the best test of comparative efficacy and tolerability.
A double-blind placebo controlled study of desipramine in the treatment of ADD: I. Efficacy.
It is suggested that DMI can be an effective treatment in the management of pediatric patients with ADDH, including patients who failed to respond to stimulants.