Controlled trial of ligation plus vasoconstrictor versus proton pump inhibitor in the control of acute esophageal variceal bleeding

@article{Lo2013ControlledTO,
  title={Controlled trial of ligation plus vasoconstrictor versus proton pump inhibitor in the control of acute esophageal variceal bleeding},
  author={Gin-Ho Lo and Daw Shyong Perng and Chi-Yang Chang and Chi‐Ming Tai and Huay-Min Wang and Hui-Chen Lin},
  journal={Journal of Gastroenterology and Hepatology},
  year={2013},
  volume={28}
}
Endoscopic therapy combined with vasoconstrictor was generally recommended to treat acute variceal bleeding. However, up to 30% of patients may still encounter treatment failure. 

Paper Mentions

Observational Clinical Trial
To observe and access the Effects and safety of terlipressin or high dose somatostatin/octreotide when usual dose somatostatin/octreotide fail to achieve hemostasis in patients… Expand
ConditionsEsophageal and Gastric Varices, Hemorrhage, Liver Cirrhosis
InterventionDrug
The Use of Vasoconstrictors in Acute Variceal Bleeding: How Long Is Enough?
  • G. Lo
  • Medicine
  • Clinical endoscopy
  • 2019
TLDR
If variceal bleeding is successfully controlled by endoscopic Variceal ligation, the combination of vasoconstrictors can be reduced to less than 1 day. Expand
Current Management Strategies for Acute Esophageal Variceal Hemorrhage
TLDR
A strategy in which patients are stratified by Child class, the main predictor of outcomes, is proposed, based on a review of recent evidence. Expand
Experience of Vasoactive Therapy from Esophageal Variceal Bleeding in Patients with Hepatic Cyrrosis and Syndrome of Portal Hypertension
TLDR
The presented clinical experience of the use of synthetic somatostatin analogues in complex therapy at acute esophageal variceal bleeding allows recommending their wide use in the practice of urgent surgical clinics. Expand
The Role of Adjuvant Acid Suppression on the Outcomes of Bleeding Esophageal Varices after Endoscopic Variceal Ligation
TLDR
The results of the current study suggest that adjuvant acid suppression prescription to patients who received endoscopic variceal ligation and vasoconstrictor therapy for bleeding esophageal varices may not change the rebleeding and mortality outcomes compared to that for those who receivedendoscopicvaricealLigation and Vasoconstrictionor agents without acid suppression. Expand
Short-course vasoconstrictors are adequate for esophageal variceal bleeding after endoscopic variceal ligation: A systematic review and meta-analysis
TLDR
Subgroup analysis suggested EVL with short-course vasoconstrictors is highly efficacious for esophageal variceal bleeding compared to standard combination, and clinical heterogeneity was found for the rebleeding rate for the subgroup during sensitivity analysis. Expand
Safe use of proton pump inhibitors in patients with cirrhosis
TLDR
This work aims to develop practical guidance on the safe use of PPIs in patients with cirrhosis, and to investigate the role of EMT in the development and use of these drugs. Expand
Use of Proton Pump Inhibitors in the Management of Gastroesophageal Varices
TLDR
The best available evidence supports the use of short-course (10 days) PPI post–endoscopic variceal ligation to reduce ulcer size if ulcer healing is a concern and practices such as high-dose infusion and prolonged use should be discouraged until evidence of benefit becomes available. Expand
The Efficacy of Proton Pump Inhibitor in Cirrhotics with Variceal Bleeding: A Systemic Review and Meta-Analysis
TLDR
PPI, used for >1 month, can decrease re-bleeding rate after endoscopic therapy in cirrhotic patients for prophylaxis or emergency treatment purpose and no matter how long it takes, PPI use is not associated with bleeding-related mortality. Expand
Endoscopic Therapy for Variceal Bleeding: from Patient Preparation to Available Techniques and Rescue Therapies
TLDR
The global management of patients with VB should include volume resuscitation, blood transfusion, and prevention of complications such as renal failure+/-sepsis+/-liver encephalopathy, as they drive the prognosis. Expand
Acid suppression in patients treated with endoscopic therapy for the management of gastroesophageal varices: a systematic review and meta-analysis
TLDR
The subgroup analyses showed that acid suppression could significantly decrease the incidence of bleeding in patients undergoing prophylactic EVL, rather than in patients undergoing therapeutic EVL. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 63 REFERENCES
Management of varices and variceal hemorrhage in cirrhosis.
TLDR
This review explains the three main challenges in clinical management: primary prophylaxis to prevent a first episode of hemorrhage, the treatment of acute bleeding episodes, and secondary prophymic treatment to prevent recurrence of variceal hemorrhage. Expand
Somatostatin alone or combined with emergency sclerotherapy in the treatment of acute esophageal variceal bleeding: A prospective randomized trial
TLDR
It is demonstrated that the addition of sclerotherapy significantly improves the efficacy of SMT alone for the treatment of acute variceal bleeding, although it also increases the rate of complications. Expand
A randomized controlled trial comparing ligation and sclerotherapy as emergency endoscopic treatment added to somatostatin in acute variceal bleeding.
TLDR
The use ofvariceal ligation instead of sclerotherapy as emergency endoscopic therapy added to somatostatin for the treatment of acute variceal bleeding significantly improves the efficacy and safety. Expand
Endoscopic Variceal Ligation Plus Nadolol and Sucralfate Compared With Ligation Alone for the Prevention of Variceal Rebleeding: A Prospective, Randomized Trial
TLDR
The combination of ligation, nadolol, and sucralfate (triple therapy) proved more effective than banding ligation alone in terms of prevention of variceal recurrence and upper gastrointestinal rebleeding as well asvariceal reble bleeding. Expand
Endoscopic treatment versus endoscopic plus pharmacologic treatment for acute variceal bleeding: A meta‐analysis
TLDR
In patients with AVB, pharmacologic agents improve the efficacy of endoscopic therapy to achieve initial control of bleeding and 5‐day hemostasis, yet fail to affect mortality. Expand
Emergency banding ligation versus sclerotherapy for the control of active bleeding from esophageal varices
TLDR
Banding ligation and sclerotherapy were comparable in the arresting of oozing varices, whereas ligation was superior to scler Therapy in the control of spurting varices. Expand
Short course adjuvant terlipressin in acute variceal bleeding: a randomized double blind dummy controlled trial.
TLDR
In patients with esophageal variceal bleeding, a 24-h course of terlipressin is as effective as a 72-H course when used as an adjunctive therapy to successful EVBL. Expand
Management of Acute Esophageal Variceal Hemorrhage
  • G. Lo
  • Medicine
  • The Kaohsiung journal of medical sciences
  • 2010
TLDR
A meta‐analysis showed that the combination of vasoconstrictor and endoscopic Therapy is superior to endoscopic therapy alone for controlling AEVH and prophylactic antibiotics were shown to be helpful in the prevention of bacterial infection and to prevent early variceal rebleeding. Expand
Terlipressin vs. Octreotide in Bleeding Esophageal Varices as an Adjuvant Therapy With Endoscopic Band Ligation: A Randomized Double-Blind Placebo-Controlled Trial
TLDR
The efficacy of terlipressin was not inferior to octreotide as an adjuvant therapy for the control of esophageal variceal bleed and in-hospital survival and high pulse, low hemoglobin, prothrombin time, blood in nasogastric aspiration, and portosystemic encephalopathy (PSE) were predictors of prolonged hospital stay. Expand
Prospective randomised study of effect of octreotide on rebleeding from oesophageal varices after endoscopic ligation
TLDR
Octreotide significantly reduces recurrent bleeding and the need for balloon tamponade in patients with variceal haemorrhage treated by endoscopic varicean ligation to prevent early rebleeding from varices. Expand
...
1
2
3
4
5
...