Controlled trial of ligation plus vasoconstrictor versus proton pump inhibitor in the control of acute esophageal variceal bleeding

@article{Lo2013ControlledTO,
  title={Controlled trial of ligation plus vasoconstrictor versus proton pump inhibitor in the control of acute esophageal variceal bleeding},
  author={Gin-Ho Lo and Daw Shyong Perng and Chi-Yang Chang and Chi‐Ming Tai and Huay-Min Wang and Hui-Chen Lin},
  journal={Journal of Gastroenterology and Hepatology},
  year={2013},
  volume={28}
}
Endoscopic therapy combined with vasoconstrictor was generally recommended to treat acute variceal bleeding. However, up to 30% of patients may still encounter treatment failure. 

The Use of Vasoconstrictors in Acute Variceal Bleeding: How Long Is Enough?

  • G. Lo
  • Medicine
    Clinical endoscopy
  • 2019
TLDR
If variceal bleeding is successfully controlled by endoscopic Variceal ligation, the combination of vasoconstrictors can be reduced to less than 1 day.

Current Management Strategies for Acute Esophageal Variceal Hemorrhage

TLDR
A strategy in which patients are stratified by Child class, the main predictor of outcomes, is proposed, based on a review of recent evidence.

Experience of Vasoactive Therapy from Esophageal Variceal Bleeding in Patients with Hepatic Cyrrosis and Syndrome of Portal Hypertension

TLDR
The presented clinical experience of the use of synthetic somatostatin analogues in complex therapy at acute esophageal variceal bleeding allows recommending their wide use in the practice of urgent surgical clinics.

Effects of Proton Pump Inhibitor on Gastroesophageal Varices of Cirrhosis: A Randomized Controlled Trial

TLDR
PPI does not appear to reduce variceal bleeding and adverse events in patients with cirrhosis after endoscopic therapy, and the average hospitalization expense of Patients in the PPI group was higher than that of patients in the non-PPI group.

Short-course vasoconstrictors are adequate for esophageal variceal bleeding after endoscopic variceal ligation: A systematic review and meta-analysis

TLDR
Subgroup analysis suggested EVL with short-course vasoconstrictors is highly efficacious for esophageal variceal bleeding compared to standard combination, and clinical heterogeneity was found for the rebleeding rate for the subgroup during sensitivity analysis.

Necessity of vasoconstrictors for esophageal variceal bleeding after endoscopic ligation: A systematic review and meta-analysis

TLDR
In patients with acute esophageal variceal bleeding after EVL, 5-day and 6-week mortality rates were similar regardless of vasoconstrictor use, and considering the controversial 5- day rebleeding rate, short course of vasodilator use based on current evidence may be reasonable.

Safe use of proton pump inhibitors in patients with cirrhosis

TLDR
This work aims to develop practical guidance on the safe use of PPIs in patients with cirrhosis, and to investigate the role of EMT in the development and use of these drugs.

Use of Proton Pump Inhibitors in the Management of Gastroesophageal Varices

TLDR
The best available evidence supports the use of short-course (10 days) PPI post–endoscopic variceal ligation to reduce ulcer size if ulcer healing is a concern and practices such as high-dose infusion and prolonged use should be discouraged until evidence of benefit becomes available.

Endoscopic Therapy for Variceal Bleeding: from Patient Preparation to Available Techniques and Rescue Therapies

TLDR
The global management of patients with VB should include volume resuscitation, blood transfusion, and prevention of complications such as renal failure+/-sepsis+/-liver encephalopathy, as they drive the prognosis.

Acid suppression in patients treated with endoscopic therapy for the management of gastroesophageal varices: a systematic review and meta-analysis

TLDR
The subgroup analyses showed that acid suppression could significantly decrease the incidence of bleeding in patients undergoing prophylactic EVL, rather than in patients undergoing therapeutic EVL.

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TLDR
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The combination of ligation, nadolol, and sucralfate (triple therapy) proved more effective than banding ligation alone in terms of prevention of variceal recurrence and upper gastrointestinal rebleeding as well asvariceal reble bleeding.

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  • Medicine
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TLDR
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TLDR
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