Controlled transdermal delivery of leuprorelin by pulsed iontophoresis and ion-exchange fiber.

@article{Malinovskaja2014ControlledTD,
  title={Controlled transdermal delivery of leuprorelin by pulsed iontophoresis and ion-exchange fiber.},
  author={Kristina Malinovskaja and Timo Laaksonen and Jouni Hirvonen},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2014},
  volume={88 3},
  pages={594-601}
}
Poor transport efficacy and issues related to biological variation are major concerns in the development of novel iontophoretic devices for the transdermal delivery of therapeutic peptides. The objective of this study was to examine the impact of constant and pulsed current on the transport of nonapeptide leuprorelin acetate across porcine epidermis. Also, the potential of drug delivery system combining iontophoresis and ion-exchange fibers as drug matrices for the delivery of the same peptide… CONTINUE READING