Controlled systemic release of interleukin-12 after gene electrotransfer to muscle for cancer gene therapy alone or in combination with ionizing radiation in murine sarcomas.

@article{Tevz2009ControlledSR,
  title={Controlled systemic release of interleukin-12 after gene electrotransfer to muscle for cancer gene therapy alone or in combination with ionizing radiation in murine sarcomas.},
  author={Gregor Tevz and Simona Kranjc and Maja {\vC}ema{\vz}ar and Ur{\vs}ka Kamen{\vs}ek and Andrej Coer and Mojca Kr{\vz}an and Suzana Vidic and Darja Pavlin and Gregor Ser{\vs}a},
  journal={The journal of gene medicine},
  year={2009},
  volume={11 12},
  pages={
          1125-37
        }
}
BACKGROUND The present study aimed to evaluate the antitumor effectiveness of systemic interleukin (IL)-12 gene therapy in murine sarcoma models, and to evaluate its interaction with the irradiation of tumors and metastases. To avoid toxic side-effects of IL-12 gene therapy, the objective was to achieve the controlled release of IL-12 after intramuscular gene electrotransfer. METHODS Gene electrotransfer of the plasmid pORF-mIL12 was performed into the tibialis cranialis in A/J and C57BL/6… CONTINUE READING
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