Controlled study of the effects of intravenous famotidine on intragastric pH in bleeding peptic ulcers.

@article{Fullarton1991ControlledSO,
  title={Controlled study of the effects of intravenous famotidine on intragastric pH in bleeding peptic ulcers.},
  author={Grant M. Fullarton and A. M. Macdonald and Susan G Mann and Kenneth E. L. McColl},
  journal={Alimentary pharmacology & therapeutics},
  year={1991},
  volume={5 1},
  pages={77-84}
}
As blood coagulation and platelet aggregation are abolished at pH less than 5.4 the failure of antisecretory drugs to promote haemostasis in bleeding peptic ulcers may reflect inadequate pH control. This study examined the ability of famotidine, a potent, long-acting H2 blocker to maintain intragastric pH above 5.4 in patients presenting with bleeding peptic ulcers. Twenty patients with acute upper gastrointestinal haemorrhage confirmed endoscopically to be related to peptic ulceration (17… CONTINUE READING