Controlled stoichiometric synthesis of DNA-quantum dot conjugates using Ni-mediated coordination chemistry.

@article{Kwon2010ControlledSS,
  title={Controlled stoichiometric synthesis of DNA-quantum dot conjugates using Ni-mediated coordination chemistry.},
  author={Haejin Kwon and Sukmin Hong and Heeyeon Kim and Youngseon Choi and Jaeseung Kim and Rita Song},
  journal={Chemical communications},
  year={2010},
  volume={46 47},
  pages={
          8959-61
        }
}
An oligonucleotide modified with Ni-nitrilotriacetate (NTA) was successfully synthesized and used for the stoichiometric functionalization of QDs. This synthetic approach allowed for the facile preparation of DNA-QD conjugates with a defined DNA/QD ratio using well-known Ni-histidine coordination chemistry. A FRET based DNA-QD nanoprobe was prepared using this method highlighting the great potential of this synthetic strategy. 

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