Controlled reperfusion of cardiac grafts from non-heart-beating donors.

  title={Controlled reperfusion of cardiac grafts from non-heart-beating donors.},
  author={Jeffrey T Cope and Michael C. Mauney and Daniel Banks and Oliver A Binns and Nuno Fevereiro Ferreira de Lima and Scott A Buchanan and Kim S Shockey and Stuart Wilson and Irving L. Kron and Curtis G. Tribble},
  journal={The Annals of thoracic surgery},
  volume={62 5},
BACKGROUND Hearts harvested from non-heart-beating donors sustain severe injury during procurement and implantation, mandating interventions to preserve their function. We tested the hypothesis that limiting oxygen delivery during initial reperfusion of such hearts would reduce free-radical injury. METHODS Rabbits sustained hypoxic arrest after ventilatory withdrawal, followed by 20 minutes of in vivo ischemia. Hearts were excised and reperfused with blood under conditions of high arterial… CONTINUE READING

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