Controlled-release systemic delivery - a new concept in cancer chemoprevention.


Many chemopreventive agents have encountered bioavailability issues in pre-clinical/clinical studies despite high oral doses. We report here a new concept utilizing polycaprolactone implants embedded with test compounds to obtain controlled systemic delivery, circumventing oral bioavailability issues and reducing the total administered dose. Compounds were… (More)
DOI: 10.1093/carcin/bgs209


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