Controlled release polymeric ocular delivery of acyclovir

@article{Deshpande2010ControlledRP,
  title={Controlled release polymeric ocular delivery of acyclovir},
  author={Praful Balavant Deshpande and Panchaxari M Dandagi and Nayanabhirama Udupa and Shavi Gopal and Samata Jain and Surenalli G Vasanth},
  journal={Pharmaceutical Development and Technology},
  year={2010},
  volume={15},
  pages={369 - 378}
}
The aim of the present study was to formulate and evaluate controlled release polymeric ocular delivery of acyclovir. Reservoir-type ocular inserts were fabricated by sandwiching hydroxypropyl methylcellulose (HPMC) matrix film containing acyclovir between two rate controlling membranes of cellulose acetate phthalate (CAP). The solubility and dissolution rate of poorly soluble acyclovir was enhanced by preparing binary systems with β-cyclodextrin and then incorporated into HPMC matrix. Nine… 
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