Controlled release of simvastatin acid using cyclodextrin inclusion system.

  title={Controlled release of simvastatin acid using cyclodextrin inclusion system.},
  author={Masao Yoshinari and Kenichi Matsuzaka and Sadamitsu Hashimoto and Kazuyuki Ishihara and Takashi Inoue and Yutaka Oda and Takaharu Ide and Teruo Tanaka},
  journal={Dental materials journal},
  volume={26 3},
Simvastatin acid (SVA) has been reported to stimulate bone formation by increasing expression of BMP-2 in osteoblasts. Due to their multi-functional characteristics and bioadaptability, cyclodextrins (CDs) are capable of forming inclusion complexes with many drugs by including a whole drug molecule inside their cavity. In the present study, we prepared SVA/CD inclusion complex solutions with different pH values. These were then used to determine their SVA release behavior after coating on… CONTINUE READING

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Simvastatin stimulates bone formation around titanium implants in rat tibiae

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