Controlled-release of epidermal growth factor from cationized gelatin hydrogel enhances corneal epithelial wound healing.

@article{Hori2007ControlledreleaseOE,
  title={Controlled-release of epidermal growth factor from cationized gelatin hydrogel enhances corneal epithelial wound healing.},
  author={Kuniko Hori and Chie Sotozono and Junji Hamuro and Kenta Yamasaki and Yu Kimura and Makoto Ozeki and Yasuhiko Tabata and Shigeru 4 Kinoshita},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2007},
  volume={118 2},
  pages={169-76}
}
We designed a new ophthalmic drug-delivery system for epidermal growth factor (EGF) from the biodegradable hydrogel of cationized gelatin. We placed a cationized gelatin hydrogel (CGH) with incorporated (125)I-labelled EGF in the conjunctival sac of mice and measured the residual radioactivity at different times to evaluate the in vivo profile of EGF release. Approximately 60-67% and 10-12% of EGF applied initially remained 1 and 7 days after application, respectively; whereas EGF delivered in… CONTINUE READING