Controlled release of donepezil intercalated in smectite clays.

  title={Controlled release of donepezil intercalated in smectite clays.},
  author={Jin Kuen Park and Young Bin Choy and Jae-Min Oh and Ju Young Kim and Seong-Ju Hwang and J E Choy},
  journal={International journal of pharmaceutics},
  volume={359 1-2},
The inorganic-organic hybrid for a drug delivery system was successfully realized by intercalating donepezil molecules into smectite clays (laponite XLG, saponite, and montmorillonite). According to the powder XRD patterns, TG profiles, and FT-IR spectra, it was confirmed that donepezil molecules were well stabilized in the interlayer space of clay via mono or double layer stacking. The adsorption amount and molecular structure of donepezil appeared to depend on the cation exchange capacity of… CONTINUE READING

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