Controlled release and dura mater permeability of lidocaine and ibuprofen from injectable poloxamer-based gels.

@article{Paavola1998ControlledRA,
  title={Controlled release and dura mater permeability of lidocaine and ibuprofen from injectable poloxamer-based gels.},
  author={Anne Paavola and Jouko K Yliruusi and Per Rosenberg},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={1998},
  volume={52 1-2},
  pages={169-78}
}
Epidural administration of drugs is becoming more common in the treatment of severe forms of pain. To improve present therapies, a long-acting single-dose gel injection would be beneficial. The present study investigated the use of three different polymers as additives in injectable poloxamer gel in controlling the drug release. The release of lidocaine.HCl and ibuprofen.NA from 25% poloxamer (PO) gel and poloxamer gel with hydroxypropylmethylcellulose (HPMC), sodium carboxymethylcellulose (CMC… CONTINUE READING