Controlled penetration of ceramides into and across the stratum corneum using various types of microemulsions and formulation associated toxicity studies.

@article{Sahle2014ControlledPO,
  title={Controlled penetration of ceramides into and across the stratum corneum using various types of microemulsions and formulation associated toxicity studies.},
  author={Fitsum Feleke Sahle and Johannes Wohlrab and Reinhard H. H. Neubert},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2014},
  volume={86 2},
  pages={244-50}
}
Several skin diseases such as psoriasis and atopic dermatitis are associated with the depletion or disturbance of stratum corneum (SC) lipids such as ceramides (CERs), free fatty acids and cholesterol. Studies suggested that replenishment of these lipids might help to treat diseased, affected or aged skin. With this premises in mind, there are some formulations in the market that contain SC lipids and currently, to facilitate permeation of the lipids deep into the SC, various CERs, and other SC… CONTINUE READING