Controlled ovarian hyperstimulation for IVF: impact on ovarian, endometrial and cervical cancer--a systematic review and meta-analysis.

@article{Siristatidis2013ControlledOH,
  title={Controlled ovarian hyperstimulation for IVF: impact on ovarian, endometrial and cervical cancer--a systematic review and meta-analysis.},
  author={Charalampos Siristatidis and Theodoros N. Sergentanis and Prodromos Kanavidis and Maria Giovanna Trivella and Marianthi Sotiraki and Ioannis Mavromatis and Theodora Psaltopoulou and Alkistis Skalkidou and Eleni Th Petridou},
  journal={Human reproduction update},
  year={2013},
  volume={19 2},
  pages={
          105-23
        }
}
BACKGROUND In response to the ongoing debate on the long-term effects of assisted reproduction technologies, such as IVF, we systematically reviewed and meta-analyzed available evidence on the association between controlled ovarian hyperstimulation for IVF and risk of ovarian, endometrial and cervical cancer. METHODS Eligible studies were identified and pooled effect estimates for relative risk (RR) were calculated by cancer type among two reference groups (general population or infertile… Expand
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TLDR
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Does ovarian stimulation for IVF increase gynaecological cancer risk? A systematic review and meta-analysis.
TLDR
Ovarian stimulation for IVF does not increase the gynaecologic cancer risk, whether hormone-dependent endometrial and breast cancer or non-hormone-dependent ovarian and cervical cancer. Expand
Risk of ovarian cancer in women treated with ovarian stimulating drugs for infertility.
TLDR
There was no convincing evidence of an increase in the risk of invasive ovarian tumours with fertility drug treatment in women treated with ovulation stimulating drugs for subfertile women. Expand
Impact of infertility and assisted reproductive technology on cancer risk
TLDR
It is suggested that infertile women have a higher risk of ovarian and endometrial cancer, but not breast cancer, and the possible increase in ovarian tumor risk following ART treatments needs to be investigated further. Expand
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TLDR
Women can be reassured that fertility drugs do not appear to significantly increase the risk of invasive ovarian, endometrial, breast or other cancers, while achieving a pregnancy at an earlier age is a significant protective factor. Expand
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TLDR
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Risk of endometrial cancer in women treated with ovary-stimulating drugs for subfertility.
TLDR
The quality of evidence was very low, due to serious risk of bias and indirectness, and the association between the use of ovary-stimulating drugs for the treatment of subfertility and the risk of endometrial cancer was not evaluated. Expand
A Potential Pathogenic Link Between Cancer of Female Reproductive System and Infertile Women Treated With Assisted Reproduction Techniques
TLDR
The objective of this review is to summarize the latest data of ovarian hyperstimulation and IVF, associated with the risk of gynecological tract cancer development. Expand
Long-Term Risk of Ovarian Cancer and Borderline Tumors After Assisted Reproductive Technology.
TLDR
Increased ovarian cancer risk in ART-treated women compared with the general population is likely explained by nulliparity rather than ART treatment, and the increased risk of borderline ovarian tumors after ART must be interpreted with caution. Expand
Treatment of infertility does not increase the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation.
TLDR
It is suggested that treatment for infertility does not significantly increase the risk of ovarian cancer among women with a BRCA mutation, and there was no significant relationship between the use of any fertility medication or IVF treatment and the subsequent riskof ovarian cancer. Expand
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