Controlled neonatal exposure to estrogens: a suitable tool for reproductive aging studies in the female rat.

@article{Rodriguez1993ControlledNE,
  title={Controlled neonatal exposure to estrogens: a suitable tool for reproductive aging studies in the female rat.},
  author={Paula Rodriguez and Carmen Fern{\'a}ndez-Galaz and Antonio Tejero},
  journal={Biology of reproduction},
  year={1993},
  volume={49 2},
  pages={387-92}
}
The present study was designed to determine whether the modification of exposure time to large doses of estrogens provided a reliable model for early changes in reproductive aging. Silastic implants containing estradiol benzoate (EB) in solution were placed into 5-day-old female Wistar rats and removed 1 day (Ei1 group) or 5 days (Ei5) later. In addition, 100 micrograms [corrected] EB dissolved in 100 microliters corn oil was administered s.c. to another group (EI). Control rats received either… CONTINUE READING
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