Controlled loading of oligodeoxyribonucleotide monolayers onto unoxidized crystalline silicon; fluorescence-based determination of the surface coverage and of the hybridization efficiency; parallel imaging of the process by Atomic Force Microscopy

@article{Cattaruzza2006ControlledLO,
  title={Controlled loading of oligodeoxyribonucleotide monolayers onto unoxidized crystalline silicon; fluorescence-based determination of the surface coverage and of the hybridization efficiency; parallel imaging of the process by Atomic Force Microscopy},
  author={Fabrizio Cattaruzza and Antonio Cricenti and Alberto Flamini and Marco Girasole and Giovanni Longo and Tommaso Prosperi and Giuseppina Andreano and Luciano Cellai and Emanuele Chirivino},
  journal={Nucleic Acids Research},
  year={2006},
  volume={34},
  pages={e32 - e32}
}
Unoxidized crystalline silicon, characterized by high purity, high homogeneity, sturdiness and an atomically flat surface, offers many advantages for the construction of electronic miniaturized biosensor arrays upon attachment of biomolecules (DNA, proteins or small organic compounds). This allows to study the incidence of molecular interactions through the simultaneous analysis, within a single experiment, of a number of samples containing small quantities of potential targets, in the presence… CONTINUE READING

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