Controlled induction of a pseudarthrosis: a study using a rodent model.

  title={Controlled induction of a pseudarthrosis: a study using a rodent model.},
  author={Luise J Harrison and James Cunningham and Lennart Str{\"o}mberg and Allen E Goodship},
  journal={Journal of orthopaedic trauma},
  volume={17 1},
OBJECTIVES This study aimed to test the hypothesis that under standardized mechanical and biologic conditions, the process of indirect bone repair in a rodent species could be manipulated to form a reproducible, atrophic, fibrous pseudarthrosis. DESIGN The model used comprised a mid-diaphyseal, transverse osteotomy in the rat femur, stabilized via a precision miniature external fixator, a constant axial fixation stiffness being defined by a specific frame geometry. MAIN OUTCOME MEASUREMENTS… CONTINUE READING

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