Controlled in vivo degradation of genipin crosslinked polyethylene glycol hydrogels within osteochondral defects.

@article{Ferretti2006ControlledIV,
  title={Controlled in vivo degradation of genipin crosslinked polyethylene glycol hydrogels within osteochondral defects.},
  author={Mario Ferretti and Kacey G Marra and Kenji Kobayashi and Alicia J Defail and Constance R. Chu},
  journal={Tissue engineering},
  year={2006},
  volume={12 9},
  pages={2657-63}
}
Polyethylene glycol (PEG) hydrogels show promise as scaffolds for growth factor delivery to enhance cartilage repair. However, methods to control growth factor release in vivo are needed. We have recently shown that in vitro polymer degradation and in vitro growth factor release kinetics can be altered using PEG crosslinked with different concentrations of genipin. However, the degradation and behavior of PEG-genipin in vivo within the cartilage repair site are unknown. This study was conducted… CONTINUE READING
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