Controlled expansion of human endothelial cell populations by Cre-loxP-based reversible immortalization.

@article{Noguchi2002ControlledEO,
  title={Controlled expansion of human endothelial cell populations by Cre-loxP-based reversible immortalization.},
  author={Hirofumi Noguchi and Naoya Kobayashi and Karen A. Westerman and Masakiyo Sakaguchi and Teru Okitsu and Toshinori Totsugawa and Takamasa Watanabe and Toshihisa Matsumura and Toshiyoshi Fujiwara and Tadayoshi Ueda and Masahiro Miyazaki and Noriaki Tanaka and Philippe Leboulch},
  journal={Human gene therapy},
  year={2002},
  volume={13 2},
  pages={321-34}
}
Endothelial cells (ECs) play multiple physiological functions and are central to many pathological processes. Various biological studies as well as cell and gene therapy applications would benefit substantially from a procedure that would result in the expansion in culture of large numbers of highly differentiated human ECs. Here, we report the amplification in vitro of human EC populations, which occurred during the first phase of reversible immortalization resulting from the retroviral… CONTINUE READING

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